SphingoTec GmbH develops innovative biomarkers for diagnosis, prediction and monitoring of acute medical conditions, such as acute heart failure, acute kidney injury and circulatory shock, in order to support patient management and provide guidance for treatment strategies.
Furthermore, sphingotec develops biomarkers for the prediction of health risks, such as obesity, cardiovascular diseases and breast cancer, in order to support prevention strategies.
SphingoTec GmbH was established in 2002 and is located in Hennigsdorf near Berlin, Germany. CEO Dr. Andreas Bergmann was one of the founders of B.R.A.H.M.S. AG. As former Chief Research Officer, he was responsible for the development of the “gold standard” sepsis biomarker Procalcitonin (B.R.A.H.M.S. PCT™).
sphingotec's first-in-class biomarker tests are made available on its proprietary whole-blood point-of-care Nexus IB10 platform for convenient and rapid testing in near-patient and laboratory settings alongside a broad portfolio of standard-of-care tests for acute care. For high-throughput testing in central laboratories, sphingotec partners with global IVD players.
The portfolio of IB10 assays includes tests for established critical care parameters such as Procalcitonin, Troponin I, CK-MB, Myoglobin, NT-proBNP, and D-Dimer as well as tests for sphingotec’s proprietary biomarkers such as DPP3, an assay for the assessment of Dipeptidyl Peptidase 3 release – one major cause of short-term organ dysfunction , and Proenkephalin (penKid®), a unique and proprietary biomarker for real-time assessment of kidney function. An IB10 assay for bioactive Adrenomedullin (bio-ADM®), a unique and proprietary biomarker for endothelial function is expected to be launched by mid-2020.
Nexus IB10 is an automated portable immunoassay system that delivers results in 20 minutes, allows easy implementation with no calibration needed and requires no sample preparation (plasma separation is done in the reagent disc). The small footprint (175 x 330 x 180 mm), light weight analyzer (2.4 kg) with battery power option, USB/PC interface, Wi-Fi and barcode reader capability was designed with the innovative Nexus IB10 user in mind.