InVivo BioTech is Europe’s largest contract manufacturer for proteins in the non-GMP sector and your partner for cost-effective outsourcing services with over 20 years of experience.
Our broad service portfolio includes the production of monoclonal antibodies from hybridoma cell lines, the manufacturing of recombinant proteins in bacterial and mammalian expression systems, the development of stable cell lines as well as the development of immunoassays for in vitro diagnostics.
Production takes place at two locations in Germany, the first being our headquarters in Hennigsdorf and the second our facility in the heart of Berlin.
All our employees are dedicated to developing premium quality products for research, diagnostic and preclinical use. As an ISO certified company, our worldwide base of customers ranges from international diagnostic companies, global biopharmaceuticals to smaller academic groups and newly founded start-ups. Since 2017 InVivo is a member of the Bruker Company group.
Our in vitro production in super spinner systems or bioreactors (2L to 100L) using high-cell density fermentation occurs exclusively under serum-free conditions. Thus, we use our proprietary medium ISF-1 to allow cost-effective production processes and high product yields. Antibodies regularly ordered in larger quantities (>1 g), qualify for our special antibody-on-demand service. We take care of the rest.
High yield up to 1 kg
Free of endotoxins and aggregates
InVivo offers diverse SARS-CoV-2 antigens and antibodies in large-scale quantities, which are suitable for the development and production of highly sensitive IVD kits. Different recombinant versions of the viral Spike protein have been transiently expressed in high yielding HEK cells. These include both subunits, S1 and S2, and RBD of the S1 subunit and matching antibodies. To cater the larger demand of bulk quantities in gram scale, InVivo offers proteins of stable CHO cell lines.
Transient Gene Expression (TGE) is commonly used for the production of recombinant proteins in mammalian cells in short times. Best results can only be achieved, if all components are carefully matched and optimized. Within a few years of research and development, InVivo established a system for the production of proteins via TGE in HEK cells. The so called InVEST system combines an optimized cell line with sophisticated vector design, effective plasmid preparation and customized cell culture.