BIO 2024German Exhibitors Numaferm GmbH

Numaferm GmbH

Booth number: 4315-01
numaferm.com

About us

Numaferm is a biotechnology company focusing on the biochemical production of peptides, proteins and “pepteins” (PEPtide & proTEINS) between 2 to 600 amino acids in length. To this end, Numaferm developed Numaswitch, a biochemical production platform enabling rapid, scalable, and cost-efficient production of these biomolecules in large quantities and with high quality. The production of these molecules takes place within weeks and in a sustainable manner. The broad spectrum of our customers, which includes pharmaceuticals, agriculture, veterinary medicine, generics, and cosmetics, highlights the versatile application of our products across diverse industries.

Lyohilized peptides and proteins packaged and ready for shipping.

The heart of Numaferm: the dedicated NumaTeam.

Lyophilized peptides and proteins being weighed and packaged.

Cell line generation by the Molecular Biology Department.

Peptides and proteins undergo water-based purification processes.

For cell line development, techniques like agarose gel electrophoresis are employed.

Address

Numaferm GmbH
Merowingerplatz 1a
40225 Düsseldorf
Germany

Phone:  +49 211 97532900

Contact person:

Dr. Christian Schwarz
CEO
E-mail: christian.schwarz@numaferm.com
Phone: +49 211 975 32900

Roxann Guerrette, Ph.D
Director, Business Development USA
E-mail: rox.guerrette@numaferm.com
Phone: +1 628 502-4945

Products & Services

Numaferm provides a biochemical production platform for the easy and efficient synthesis of peptides and proteins. In this novel method, target proteins are genetically fused to Switchtag libraries, promoting high-titer production of fusion proteins within E. coli cells as inclusion bodies. Switchtags play a crucial role in facilitating the efficient refolding of fusion proteins, while the unique Numacut TEV protease removes the Switchtag from the targets in a traceless manner. Evolved through artificial intelligence and directed evolution approaches, the Numacut TEV protease demonstrates expanded substrate tolerance compared to the wild type enzyme, allowing the release of targets with native N-termini. Numaswitch addresses the challenge of low refolding efficiencies in inclusion body methods, enabling high product yields and purities. Production of these molecules is accomplished within weeks and in an environmentally sustainable manner, highlighting the technology's advantages.

Numacut TEV Protease

The Numacut TEV protease is an improved variant of the Tobacco Etch Virus (TEV) protease with broadened substrate tolerance in comparison to the wild type enzyme. Evolved by artificial intelligence and directed evolution approaches, the recognition site of the TEV protease (ENLYFQ/S) was broadened to ENLYFQ/X (X: any amino acid, except P). Fusion proteins featuring the ENLYFQ sequence are efficiently cleaved between Q and X releasing N-terminal native target peptides or proteins.
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Our Numacut TEV protease which make traceless cleavage of fusion proteins possible.

Numaswitch technology

Numaswitch is a biochemical production platform for easy and efficient peptide and protein production. Target proteins are fused to Switchtags which promote the high-titer production within E. coli cells as inclusion bodies. Switchtags trigger the efficient refolding of fusion proteins, while the Numacut TEV protease removes the desired targets tracelessly from the Switchtag. This technology resolves the challenge of low refolding efficiencies resulting in high product yields and purities.
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The Numaswitch technology makes recombinant production of peptides and proteins easy.

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