In iterative cycles of computer aided directed evolution, we generate enzymes with unmet performance, tailored to your needs. The BioEngine® combines comprehensive in silico studies and experimental screening of enzyme libraries in every round of evolution. Predicted combinations of critical residues for the enzyme’s activity are used to create small libraries, which are screened for improved enzyme variants. Our smart libraries allow the use of high throughput GC and HPLC analytics measuring the real reaction components and giving detailed insights to each reaction.